AA Amyloidosis Secondary to Horton's Disease Complicated by Pulmonary Fibrosis: A Very Challenging Diagnosis and Therapy

AA amyloidosis is a classic and serious complication of many chronic inflammatory processes, whether infectious, autoimmune, or neoplastic origin. It frequently complicated by kidney damage, often in the form nephrotic syndrome. Giant cell arteritis common elderly; however, it rarely causes amyloidosis. We report rare case Horton disease causing an elderly patient with history myopericarditis repeated episodes congestive heart failure. Patient was treated initially dual therapy based on corticosteroids anti TNF (Tocilizumab) associated failure recommended European society cardiology (ESC 2021 guidelines Heart Failure). The initial outcome favorable but later involvement lungs; pulmonary fibrosis, responsible for pleural effusion non controlled spite high dose loop diuretics punction. died shortly after her second hospitalization due to respiratory insufficiency.